期刊
SCIENTIFIC REPORTS
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep03760
关键词
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资金
- Presidential Early Career Award for Scientists and Engineers (PECASE)
- Army Research Office (ARO) Life Sciences Division
- ARO Young Investigator Award
- National Science Foundation (NSF) CAREER Award
- NSF CBET Biophotonics Program
- NSF EFRI Award
- Office of Naval Research (ONR) Young Investigator Award
- National Institutes of Health (NIH) Director's New Innovator Award from the Office of the Director, National Institutes of Health [DP2OD006427]
- Directorate For Engineering [0954482] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [0954482] Funding Source: National Science Foundation
Lensfree on-chip imaging and sensing platforms provide compact and cost-effective designs for various telemedicine and lab-on-a-chip applications. In this work, we demonstrate computational solutions for some of the challenges associated with (i) the use of broadband, partially-coherent illumination sources for on-chip holographic imaging, and (ii) multicolor detection for lensfree fluorescent on-chip microscopy. Specifically, we introduce spectral demultiplexing approaches that aim to digitally narrow the spectral content of broadband illumination sources (such as wide-band light emitting diodes or even sunlight) to improve spatial resolution in holographic on-chip microscopy. We also demonstrate the application of such spectral demultiplexing approaches for wide-field imaging of multicolor fluorescent objects on a chip. These computational approaches can be used to replace e.g., thin-film interference filters, gratings or other optical components used for spectral multiplexing/demultiplexing, which can form a desirable solution for cost-effective and compact wide-field microscopy and sensing needs on a chip.
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