期刊
SCIENTIFIC REPORTS
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep04169
关键词
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资金
- National Science Fund for Distinguished Young Scholars [20925520]
- National Natural Science Foundation of China [61001035, 21235003]
- Chen Guang'' project of the Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [10CG42]
- Innovation Program of Shanghai Municipal Education Commission [12YZ004]
- Shanghai Science and Technology Committee [11DZ2272100]
Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcome this problem, we propose a novel concept by introducing a magneto-controlled moveable architecture (MCMA) instead of the conventional surface-fixed architecture. As a model, human breast cancer cells were used in this study. The results showed that a detection range from 100 to 13106 cells could be achieved. Moreover, the whole detection cycle, including the measurement and the regeneration, could be completed in only 2 min. Thus, usability and excellent performance can be achieved in a single biosensor.
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