期刊
SCIENTIFIC REPORTS
卷 3, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep02162
关键词
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资金
- Shanghai 1000 Plan [SH01068]
- program for professor of special appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [P2009011]
- National Natural Science Foundation of China [21074095, 21174107]
- New Century Excellent Talents in Universities of Ministry of Education [NCET-10-0627]
- Ph.D. program Foundation of Ministry of Education [20110072110048]
- Fok Ying Tong Education Foundation [132018]
- Shanghai Pujiang program [10PJ1409900]
- fundamental research funds for the Central Universities
Recently, smart polymer vesicles have attracted increasing interest due to their endless potential applications such as tunable delivery vehicles for the treatment of degenerative diseases. However, the evolution of stimuli-responsive vesicles from bench to bedside still seems far away for the limitations of current stimuli forms such as temperature, light, redox, etc. Since ultrasound combined with chemotherapy has been widely used in tumor treatment and the pH in tumor tissues is relatively low, we designed herein a novel polymer vesicle that respond to both physical (ultrasound) and chemical (pH) stimuli based on a PEO-b-P(DEA-stat-TMA) block copolymer, where PEO is short for poly(ethylene oxide), DEA for 2-(diethylamino)ethyl methacrylate and TMA for (2-tetrahydrofuranyloxy)ethyl methacrylate. These dually responsive vesicles show noncytotoxicity below 250 mu g/mL and can encapsulate anticancer drugs, exhibiting retarded release profile and controllable release rate when subjected to ultrasound radiation or varying pH in tris buffer at 37 degrees C.
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