期刊
SCIENTIFIC REPORTS
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep02587
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
- Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes, Meijo University
- Core Research for Evolutional Science and Technology
- SENSHIN Medical Research
- Grants-in-Aid for Scientific Research [24390085, 25860999, 24791210, 23591701] Funding Source: KAKEN
Using a very high-resolution oligonucleotide array for copy number variant (CNV) screening of samples comprising schizophrenic patients, we detected a novel CNV within the critical region (NCBI36/hg18, Chr7: 158,630,410-158,719,410) previously shown to be associated with schizophrenia. We investigated the association between the novel CNV identified in the current study and schizophrenia. Three independent samples were used: (1) Screening set, 300 Japanese schizophrenic patients (53.28 +/- 14.66 years); (2) Confirmation set, 531 schizophrenic patients (46.03 +/- 12.15 years); and (3) 711 healthy controls (47.12 +/- 11.03 years). All subjects enrolled in the study were Japanese. Chromosomal position was determined using fluorescence in situ hybridization. We identified a novel duplication within the region associated with schizophrenia identified on 7q36.3 that is adjacent to VIPR2 and is not associated with schizophrenia. In the Japanese population, the 35-kb region that harbors the common, novel CNV should be excluded from the region associated with schizophrenia on 7q36.3.
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