期刊
SCIENTIFIC REPORTS
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep02079
关键词
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资金
- Cancer Prevention Research Institute of Texas [CPRIT RP110262]
- U.S. National Institutes of Health [U54CA143837, U54CA151668]
- Office of Science of the U.S. Department of Energy [DE-AC02-06CH11357]
- World Class University Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [R33-10079]
- [CMMI-0856492]
- [CMMI-0856333]
Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of similar to 100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and computational modeling. Small NMPs (<= 100 nm) are observed to move with Red Blood Cells (RBCs), presenting an uniform radial distribution and limited near-wall accumulation. Larger NMPs tend to preferentially accumulate next to the vessel walls, in a size-dependent manner (similar to 70% for 1,000 nm NMPs). RBC-NMP geometrical interference only is responsible for this behavior. In a capillary flow, the effective radial dispersion coefficient of 1,000 nm particles is similar to 3-fold larger than Brownian diffusion. This suggests that sub-micron particles could deposit within diseased vascular districts more efficiently than conventional nanoparticles.
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