期刊
SCIENTIFIC REPORTS
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep01887
关键词
-
资金
- National High Technology Research and Development Program of China [2012AA020402]
- NSFC [31100522, 11174093]
- Specialized Research Fund for the Doctoral Program of Higher Education [20110142120038]
Three-dimensional structures of RNA-protein complexes are crucial for understanding their diverse functions. However, the number of the RNA-protein complex structures solved by experiments is still limited at present. To solve this problem, some computational protocols have been proposed to predict three-dimensional RNA-protein complex structures. But the prediction accuracies of these protocols are lower. The reason may be that these protocols don't fully incorporate the features of RNA-protein interfaces. Here we propose a novel computational protocol for three-dimensional RNA-protein complex structure prediction, 3dRPC, which applies new schemes to the discreteness of molecule and charge in docking algorithm and the construction of the reference state in scoring function in order to take account of the features of RNA-protein interfaces. This protocol achieves a high accuracy comparable to the well-developed algorithms for three-dimensional structure prediction of protein-protein complexes when tested on a RNA-protein docking benchmark.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据