期刊
SCIENTIFIC REPORTS
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep02053
关键词
-
资金
- Swedish Research Council
- Swedish Cancer Foundation
- Karolinska Institute Foundation
- Karolinska Institute
- Torsten Soderbergs foundation
- Soderbergs stiftelse
- Tianjin Natural Science Foundation (CMM-Tianjin) [09ZCZDSF04400]
- European Union Integrated Project of Metoxia [222741]
- European Research Council (ERC) advanced grant ANGIOFAT [250021]
- Belven foundation
- Foundation for Geriatric Research
- Stones Foundation
- Swedish Research Council [523-2012-2291]
- Foundation of Gamla Tjanarinnor
- Alzheimer Foundation
- Swedish Society of Medicine
- European Union, FP7 (IDEA)
The functional impact of amyloid peptides (Abs) on the vascular system is less understood despite these pathologic peptides are substantially deposited in the brain vasculature of Alzheimer's patients. Here we show substantial accumulation of Abs 40 and 42 in the brain arterioles of Alzheimer's patients and of transgenic Alzheimer's mice. PurifiedAbs 1-40 and 1-42 exhibited vascular regression activity in the in vivo animal models and vessel density was reversely correlated with numbers and sizes of amyloid plaques in human patients. A significant high number of vascular cells underwent cellular apoptosis in the brain vasculature of Alzheimer's patients. VEGF significantly prevented Ab-induced endothelial apoptosis in vitro. Neuronal expression of VEGF in transgenic mice restored memory behavior of Alzheimer's. These findings provide conceptual implication of improvement of vascular functions as a novel therapeutic approach for the treatment of Alzheimer's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据