期刊
SCIENTIFIC REPORTS
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep01280
关键词
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资金
- Deutsche Forschungsgemeinschaft [DFG WA 2804]
- Experimental and Clinical Research Center
- Max Delbruck Center for Molecular Medicine
- Charite Medical Faculty in Berlin
Magnetic resonance imaging (MRI) provides the opportunity of tracking cells in vivo. Major challenges in dissecting cells from the recipient tissue and signal sensitivity constraints albeit exist. In this study, we aimed to tackle these limitations in order to study inflammation in autoimmune encephalomyelitis. We constructed a very small dual-tunable radio frequency (RF) birdcage probe tailored for F-19 (fluorine) and H-1 (proton) MR mouse neuroimaging. The novel design eliminated the need for extra electrical components on the probe structure and afforded a uniform B-1(+)-field as well as good SNR. We employed fluorescently-tagged F-19 nanoparticles and could study the dynamics of inflammatory cells between CNS and lymphatic system during development of encephalomyelitis, even within regions of the brain that are otherwise not easily visualized by conventional probes. F-19/H-1 MR Neuroimaging will allow us to study the nature of immune cell infiltration during brain inflammation over an extensive period of time.
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