期刊
SCIENTIFIC REPORTS
卷 2, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep00406
关键词
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资金
- National Natural Science Foundation of China [51011130028, 50990063, 50973095]
- Zhejiang Provincial Natural Science Foundation of China [R4110030]
- Science and Technology Department of Zhejiang Provincial [2011R10077]
- Fundamental Research Funds for the Central Universities of China [2011QNA4030]
- Interdisciplinary Laboratory for Nanoscale Science and Technology & Material Analysis Station, National Institute for Materials Science (NIMS), Japan
Information on how cells interface with nanomaterials in biological environments has important implications for the practice of nanomedicine and safety consideration of nanomaterials. However, our current understanding of nanobiological interactions is still very limited. Here, we report the direct observation of nanomaterial bio-complex formation (other than protein corona) from nanomaterials dispersed in biologically relevant solutions. We observed highly selective binding of the components of cell culture medium and phosphate buffered saline to ZnO and CuO nanoparticles, independent of protein molecules. Our discoveries may provide new insights into the understanding of how cells interact with nanomaterials.
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