期刊
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
卷 52, 期 2, 页码 135-146出版社
SCIENCE PRESS
DOI: 10.1007/s11427-009-0018-3
关键词
protein phosphorylation; dephosphorylation; PP2A; structure; mechanism
类别
资金
- NIH [R01 CA123155]
- Tsinghua University
Protein phosphatase 2A (PP2A) represents a conserved family of important protein serine/threonine phosphatases in species ranging from yeast to human. The PP2A core enzyme comprises a scaffold subunit and a catalytic subunit. The heterotrimeric PP2A holoenzyme consists of the core enzyme and a variable regulatory subunit. The catalytic subunit of PP2A is subject to reversible methylation, mediated by two conserved enzymes. Both the PP2A core and holoenzymes are regulated through interaction with a large number of cellular cofactors. Recent biochemical and structural investigation reveals critical insights into the assembly and function of the PP2A core enzyme as well as two families of holoenzyme. This review focuses on the molecular mechanisms revealed by these latest advances.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据