期刊
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
卷 51, 期 11, 页码 1039-1044出版社
SCIENCE PRESS
DOI: 10.1007/s11427-008-0126-5
关键词
rhEGF microspheres; the diabetic ulcer; recombinant human epidermal growth factor; PLGA
类别
资金
- National Natural Science Foundation of China [50373033]
- Applied Foundational Research Key Fund of Tianjin [05YFJZJC01001]
- International Cooperative Fund of Tianjin [05YFGHHZ20070]
In this study the w/o/w extraction-evaporation technique was adopted to prepare poly(lactic-co-glycolic acid) (PLGA) microspheres loading recombinant human epidermal growth factor (rhEGF). The microspheres were characterized for morphology by transmission electron microscopy (TEM) and particle size distribution. The release performances, the proliferation effects and therapeutic effects of rhEGF-loaded PLGA microspheres were all studied. The results showed that these spherical microspheres had a narrow size distribution and a high drug encapsulation efficiency (85.6%). RhEGF-loaded microspheres enhanced the growth rate of fibroblasts and wound healing more efficiently than pure rhEGF. The number of the proliferating cell nuclear antigen (PCNA) in the epidermis layer with the microsphere treatment was significantly larger than those of the control groups. Overall locally sustained delivery of rhEGF from biodegradable PLGA microspheres may serve as a novel therapeutic strategy for diabetic ulcer repair.
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