3.8 Article

Repair effect of diabetic ulcers with recombinant human epidermal growth factor loaded by sustained-release microspheres

期刊

SCIENCE IN CHINA SERIES C-LIFE SCIENCES
卷 51, 期 11, 页码 1039-1044

出版社

SCIENCE PRESS
DOI: 10.1007/s11427-008-0126-5

关键词

rhEGF microspheres; the diabetic ulcer; recombinant human epidermal growth factor; PLGA

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资金

  1. National Natural Science Foundation of China [50373033]
  2. Applied Foundational Research Key Fund of Tianjin [05YFJZJC01001]
  3. International Cooperative Fund of Tianjin [05YFGHHZ20070]

向作者/读者索取更多资源

In this study the w/o/w extraction-evaporation technique was adopted to prepare poly(lactic-co-glycolic acid) (PLGA) microspheres loading recombinant human epidermal growth factor (rhEGF). The microspheres were characterized for morphology by transmission electron microscopy (TEM) and particle size distribution. The release performances, the proliferation effects and therapeutic effects of rhEGF-loaded PLGA microspheres were all studied. The results showed that these spherical microspheres had a narrow size distribution and a high drug encapsulation efficiency (85.6%). RhEGF-loaded microspheres enhanced the growth rate of fibroblasts and wound healing more efficiently than pure rhEGF. The number of the proliferating cell nuclear antigen (PCNA) in the epidermis layer with the microsphere treatment was significantly larger than those of the control groups. Overall locally sustained delivery of rhEGF from biodegradable PLGA microspheres may serve as a novel therapeutic strategy for diabetic ulcer repair.

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