期刊
SCIENCE IN CHINA SERIES B-CHEMISTRY
卷 52, 期 1, 页码 15-19出版社
SCIENCE PRESS
DOI: 10.1007/s11426-009-0008-0
关键词
aggregation-induced emission; biosensor; cell imaging
资金
- Research Grants Council of Hong Kong [603008, 601608, 602707]
- National Natural Science Foundation of China [20634020]
- CAO GuangBiao Foundation of Zhejiang University
A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate material for cell imaging as a sensitive, selective and cytocompatible biosensor.
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