Intracellular pH-sensitive delivery CaCO3 nanoparticles templated by hydrophobic modified starch micelles

A novel method of preparing CaCO3 nanoparticles using a starch-octanoic acid micelle as the template was engineered. The CaCO3 nanoparticles engineered via this method displayed stable physiochemical properties, high drug-encapsulation efficiency, low cell cytotoxicity and an intracellular pH-sensitive release profile, which indicate the potential for further applications.