Frit-free PDMS microfluidic device for chromatographic separation and on-chip detection

A simple frit-free PDMS (polydimethylsiloxane) microfluidic chromatographic device, packed with diatomaceous earth (DE) microparticles as a normal phase stationary material using iron oxide magnetic nanoparticles is described. The separation of two model dyes was successfully demonstrated by integrating on-chip fibre optic detection to create a lab on a chip type of device.