4.6 Article

Copper catalyzed three-component synthesis of benzothiazolones from o-iodoanilines, DMF, and potassium sulfide

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RSC ADVANCES
卷 4, 期 12, 页码 6090-6093

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra46803h

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资金

  1. Natural Science Foundation of China [21072054]
  2. Research Project of Chinese Ministry of Education [213027A, 20094306120003]
  3. Training Program Foundation for the Young Talents by Hunan Normal University [ET21003]
  4. Hunan Provincial Natural Science Foundation [12JJ2009]
  5. Scientific Research Fund of Hunan Provincial Education Department [12A095]
  6. Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province

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A copper catalyzed three-component reaction was developed for the synthesis of benzothiazolones. In the presence of CuBr2, the reaction of o-iodoanilines and K2S with DMF proceeded smoothly and generated the corresponding benzothiazolones with good isolated yields. DMF functioned both as the carbon monoxide source and as the reaction medium in this reaction.

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