New rearranged limonoids from Walsura cochinchinensis

Sixteen new limonoids, walsucochinoids C-R (1-16) incorporating a rearranged carbon skeleton, were isolated from the twigs and leaves of Walsura cochinchinensis. Their structures were established by detailed interpretation of spectroscopic data with those of 1 and 10 being secured by single-crystal X-ray diffraction experiments. Bioassays revealed that walsucochinoids D (2) and E (3) were mild mouse and human 11 beta-HSD1 inhibitors with IC50 values of 13.4 +/- 1.7 and 8.25 +/- 0.69 mu M, respectively.