期刊
RSC ADVANCES
卷 4, 期 51, 页码 26956-26980出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra02129k
关键词
-
资金
- Spanish government [CTQ2012-38616-C02-02, CTQ-2010-20541-C03]
- Spanish Ministerio de Economia y Competitividad
The i-motif structure is formed in cytosine-rich sequences, its building block being the cytosine.cytosine + base pair. This structure is particularly stable at pH values below physiological (similar to 7.4) and, because of that, it has not attracted as much biological interest as other non-canonical structures such as the G-quadruplex. Nowadays, the proposal of potential roles in vivo, as well as nanotechnological applications, has produced an increasing interest in its study. In this context, the present work provides an overall picture of the i-motif structure. Those aspects related to formation and stability, such as chemical modifications or the interaction with ligands, are discussed. Special attention has been made to the i-motif structures that could have a hypothetical role in vivo, such as those present near the promoter region of several oncogenes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据