On-water synthesis of novel trisubstituted 1,3-thiazoles via microwave-assisted catalyst-free domino reactions

A clean, efficient and catalyst-free multicomponent domino reaction of arylglyoxals, cyclic 1,3-dicarbonyls and thioamides in aqueous media under microwave conditions is reported. A wide variety of trisubstituted thiazoles can be synthesized in good to very good yields using this green protocol. The salient features of this methodology are: catalyst-free reaction, water as reaction medium, short reaction time, good yields, use of microwave heating, and no harmful by-products.