Fluorogenic sensing of H2S in blood and living cells via reduction of aromatic dialkylamino N-oxide

A fluorescent chemodosimeter, N-oxide of 7-diethylamino-4-methylcoumarin, was developed for H2S detection based on a new water soluble aromatic dialkylamine N-oxide group and their selectivity and sensitivity for fluorescent detection of H2S were evaluated in aqueous solution and blood media. Fluorescence sensing of H2S was also achieved in MCF-7 cells.