期刊
RSC ADVANCES
卷 4, 期 56, 页码 29729-29734出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra05209a
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资金
- Sheikh Zayed Institute for Pediatric Surgical Innovation (RAC) [30000174, 30001489]
We describe Prussian blue nanoparticles (PB NPs) for laser-induced photothermal therapy (PTT) of tumors. The PB NPs exhibit strong absorbance at near infrared (NIR) wavelengths, are stable, non-toxic, and have 20.5% photothermal conversion efficiencies. PTT with PB NPs in a mouse model of neuroblastoma resulted in marked tumor debulking, increased tumor-free days, and decreased tumor growth rates in tumor-bearing mice. These findings demonstrate the clinical potential of PB NPs for PTT of tumors.
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