期刊
RSC ADVANCES
卷 4, 期 96, 页码 53725-53729出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra07985j
关键词
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资金
- National Natural Science Foundation of China [81172958]
- Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2012-KF01]
- Yong Academic and Technical Leader Raising Foundation of Yunnan Province [2009C1072]
Pegaharmalines A (1) and B (2), two novel beta-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 mu M, respectively.
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