期刊
RSC ADVANCES
卷 4, 期 16, 页码 8191-8199出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra47453d
关键词
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资金
- Natural Science Foundation Committee of China (NSFC) [81371684, 81000666, 81220108012, 61335007, 81171395, 81328012]
- New Century Excellent Talents (NCET) in University of the Ministry of Education of China
The unique properties of gold nanoclusters (Au NCs) enable them to be functionalized as fluorescent probes or pro-drugs for biomedical application. A facile approach was introduced to synthesize nanoconjugates (Au-cRGD-MPA), which was composed of Au NCs, cyclic (Arg-Gly-Asp-DTyr-Lys) (cRGD) peptide and a near infrared (NIR) fluorescence dye (MPA). The nanoconjugates exhibited dual fluorescence in the visible range and NIR range simultaneously. The low cytotoxicity of Au-cRGD-MPA was demonstrated in MCF-7 cell line and U87 cell line. The cell affinity investigations verified the outstanding tumor-targeting capability of Au-cRGD-MPA for tumor cells. The biodistribution characteristics and tumor targeting ability of the probes were elucidated in normal nude mice and tumor-bearing mice, respectively. Attributing to the small size (less than 5 nm), the majority of the nanoconjugates metabolized from the living subjects via the kidney-bladder pathway. Additionally, Au-cRGD-MPA displayed favorable tumor-specificity in Integrin alpha(v)beta(3) over-expressed tumor-bearing (MDA-MB-231) mice. Consequently, the results demonstrated that the dual fluorescence probe is a promising candidate for tumor imaging and disease treatment monitoring.
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