Syntheses of indolo[1,2-a]quinazolinone derivatives via palladium catalyzed intramolecular C-H amidation

The synthesis of indolo[1,2-a]quinazolinone starting from 2-iodobenzamide and indole derivatives is reported. In this two-step procedure, indole is N-arylated with 2-iodobenzamide derivatives via Ullman coupling, followed by an intramolecular C-H amidation using a palladium catalyst.