Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, ready for use MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and a-amylase in only 4 hours.