Nucleophilic radiofluorination at room temperature via aziridinium intermediates

beta-[F-18]fluoroamines were radiolabeled using anchimeric assistance of the amine. The ring opening of the aziridinium intermediate by different sources of nucleophilic fluoride at RT led to both fluorinated regioisomers with F-18-incorporation yields of up to 77% at RT. The radiofluorination 2-[F-18] fluoroethylamines afforded single compounds from the alcohol precursor at RT.