期刊
RSC ADVANCES
卷 4, 期 97, 页码 54268-54281出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra10407b
关键词
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资金
- Intergration of Industry, Education and Research of Guangdong Province project [2011A091000007]
- Guangdong-Hongkong Technology Cooperation Finding [2009A091300012]
- National Natural Science Foundation of China [20974121]
Novel macromolecular star polymers with triazole and cyclodextrin (CD) segments as branch points and poly(oligo(ethylene glycol) methacrylate) (POEGMAs) as dense hydrophilic branches were synthesized via a combination of azide-alkyne click chemistry and atom transfer radical polymerization (ATRP). Firstly, a tetrafunctional linking agent (PETP) was prepared by the reaction of pentaerythritol (PE) and propargyl bromide, and then a four arm beta-CD terminated star polymer (PE-CD) was obtained through the click chemistry reaction. Finally, thermally-responsive star polymers (PE-CD-POEGMAs) with PE as the central core, triazole and CD segments as branch points, and POEGMAs as side branches were synthesized by the ATRP of MEO(2)MA and OEGMA using PE-CD terminated with bromines as macroinitiators. A study on the thermoresponsivity and morphology of PE-CD-POEGMAs indicated that polymeric nano-aggregates existed as multimolecular micelles and behaved with tunable thermosensitivity, which were driven by the strong hydrophobic-hydrophilic interactions in the inner core and outer shell. The encapsulation capacities towards multi-guest molecules were investigated and the results indicated that water soluble guests could be encapsulated by PE-CD-POEGMAs, and the guest encapsulation capacities were derived from the special star molecular structure properties of PE-CD-POEGMAs and the synergistic encapsulation phenomenon of different guest molecules. This unique amphiphilic star polymer illustrated the potential applications in supramolecular science, drug delivery and other nanotechnology applications.
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