期刊
RSC ADVANCES
卷 3, 期 26, 页码 10251-10261出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra41312h
关键词
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资金
- DBT-Biocare
- ORIGIN project [CSC0108]
- DENOVA project [CSC0205]
- TAPSUN project [NWP 0054, NWP 0055]
- INTELCOAT project
- CSIR
- [MLP-0002]
Described herein is an efficient protocol for the site selective oxidative C-H activation/acetoxylation of a series of 2-aryl/heteroaryl/thiophenyl tethered dihydroquinolinones using palladium acetate as the catalyst and iodobenzene diacetate as an oxidant. All these transformations progressed well at less sterically encumbered and electronically favourable C-H bonds to give corresponding ortho-acetoxylated derivatives in good yields. Further, acetoxylation of thiophenyl embedded dihydroquinolinones resulted in single regioisomers, acetoxylated at the C-2 position on the thiophenyl moiety. However, when the C-2 position on the thiophene unit was blocked, the acetoxy group was exclusively installed at the C-4 position. Further, we noticed that acetoxylation of dihydroquinolin-5(6H)-one-oxime did not alter ligand preferentiality to give the ortho-acetoxylated product.
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