期刊
RSC ADVANCES
卷 3, 期 40, 页码 18383-18394出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra42629g
关键词
-
资金
- EPSRC
- Ondine Biopharma
- EPSRC [EP/G067937/1, EP/K03930X/1] Funding Source: UKRI
- MRC [G0902208] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K03930X/1, EP/G067937/1, 955465] Funding Source: researchfish
- Medical Research Council [G0902208] Funding Source: researchfish
Crystal violet and 2 nm gold nanoparticles were incorporated into medical grade silicone polymers by use of a novel two-step dipping strategy using water and water-acetone mixtures. Optical microscopic examination showed that the optimised polymer incorporated dye close to the polymer surface, with minimal dye encapsulation throughout the polymer bulk. The modified polymer was stable under aqueous conditions with negligible leaching of crystal violet from the polymer into surrounding aqueous solution at 37 degrees C. Exposure of the modified silicone to low power 635 nm laser light induced the lethal photosensitisation of both Staphylococcus epidermidis and Escherichia coli. Despite the laser used not matching the absorption maximum of the crystal violet-containing silicone samples, the lethal photosensitisation was the highest reported, in terms of bacterial kill per energy dose. Furthermore, surprisingly, some statistically significant dark kill was also noted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据