期刊
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
卷 4, 期 5, 页码 445-468出版社
WILEY
DOI: 10.1002/wdev.187
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资金
- NIDDK NIH HHS [R01 DK108230] Funding Source: Medline
- NINDS NIH HHS [R21 NS067393] Funding Source: Medline
Owing to its complex structure and highly diverse cell populations, the study of hypothalamic development has historically lagged behind that of other brain regions. However, in recent years, a greatly expanded understanding of hypothalamic gene expression during development has opened up new avenues of investigation. In this review, we synthesize existing work to present a holistic picture of hypothalamic development from early induction and patterning through nuclear specification and differentiation, with a particular emphasis on determination of cell fate. We will also touch on special topics in the field including the prosomere model, adult neurogenesis, and integration of migratory cells originating outside the hypothalamic neuroepithelium, and how these topics relate to our broader theme. (C) 2015 Wiley Periodicals, Inc.
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