期刊
RSC ADVANCES
卷 3, 期 16, 页码 5422-5429出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra40552d
关键词
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资金
- Project 2HE [PONa3_00334-CUP F81D11000210007]
- ARTI strategic project Development and realization of bio-chip for molecular diagnostic and typization of human pathogenic viruses (HPV, HCV)'' of Apulia Region [PS105]
- AIRC
- MFAG [10684]
Curcumin is a natural hydrophobic polyphenol found in the powdered rhizomes of Curcuma longa. Due to its capacity to interfere with many signalling pathways, it has been shown that curcumin has potential beneficial pharmacological effects including antioxidant, anti-inflammatory, anticarcinogenic properties. However, the use of curcumin is fairly restricted because of its poor water solubility, low bioavailability, inadequate tissue absorption and degradation at alkaline pH. In the present contribution, we first verified the anti-proliferative effects of natural curcuminoids towards two different cell lines derived from an ovarian and a breast adenocarcinoma cancer. Later, curcuminoids were successfully encapsulated into reconstituted oil bodies. Once encapsulated into the triacylglycerol cores of the reconstituted oil bodies, curcumin, the most hydrophobic and active of the three curcuminoids, was better stabilized in comparison with albumin stabilization. Oil body encapsulated curcuminoids showed the same effects on cancer cell viability as the free drug, confirming the great potential of natural oil bodies as micro/nano-capsules in drug delivery applications.
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