期刊
RSC ADVANCES
卷 2, 期 9, 页码 3785-3790出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra20191g
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资金
- Deutsche Forschungsgemeinschaft [FOR 1406, Ka 880/10-1]
The [3+2]-cycloaddition of an azido tripeptide, corresponding to the left hand side of pretubulysin, with a range of alkynes, such as propiolic acid amides and propargyl ethers, allows the straightforward syntheses of libraries of tubulysin derivatives. Via this click approach, a chimera of pretubulysin and dolastatin 10, both highly potent antimitotic drug candidates, also becomes accessible.
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