期刊
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
卷 98, 期 1, 页码 101-108出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02772248.2015.1110156
关键词
malathion; oleuropein; oxidative stress; DNA damage; rat
资金
- Usak University Scientific Research Council, Usak, Turkey [2014/MF001]
The effects of acute exposure to 250 mg/kg malathion and the protective effects of 20 mg/kg oleuropein, both administered intraperitoneally, were evaluated in Wistar male rats. Malathion administration increased malondialdehyde, nitric oxide, 8-hydroxy-2-deoxyguanosine, total oxidant status, and DNA damage, yet decreased total antioxidant activity, superoxide dismutase, and catalase activities in blood, liver, and kidney. Administration of oleuropein reversed malathion-induced oxidative stress, lipid peroxidation, DNA damage, and antioxidant enzyme activity.
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