期刊
ORGANOGENESIS
卷 10, 期 2, 页码 196-207出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/org.27846
关键词
lung transplantation; decellularization; recellularization; extracellular matrix; stem; progenitor cells; induced pluripotent stem cells
资金
- NHLBI NIH HHS [U01 HL111016] Funding Source: Medline
The shortage of donor lungs for transplantation causes a significant number of patient deaths. The availability of laboratory engineered, functional organs would be a major advance in meeting the demand for organs for transplantation. The accumulation of information on biological scaffolds and an increased understanding of stem/progenitor cell behavior has led to the idea of generating transplantable organs by decellularizing an organ and recellularizing using appropriate cells. Recellularized solid organs can perform organ-specific functions for short periods of time, which indicates the potential for the clinical use of engineered solid organs in the future. The present review provides an overview of progress and recent knowledge about decellularization and recellularization-based approaches for generating tissue engineered lungs. Methods to improve decellularization, maturation of recellularized lung, candidate species for transplantation and future prospects of lung bioengineering are also discussed.
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