期刊
ORGANOGENESIS
卷 7, 期 2, 页码 101-104出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/org.7.2.16150
关键词
stem cell; mesenchymal stem cell; blood vessel; pericyte; tunica adventitia; tissue regeneration
资金
- National Institutes of Health
- Pittsburgh Foundation
- Medical Research Council
- California Institute for Regenerative Medicine
- University of Pittsburgh
- University of California at Los Angeles
- MRC [G1000816] Funding Source: UKRI
- Medical Research Council [G1000816] Funding Source: researchfish
Mesenchymal stem cells proliferate extensively in cultures of unselected, total cell isolates from multiple fetal and adult organs. Perivascular cells, principally pericytes surrounding capillaries and microvessels, but also adventitial cells located around larger arteries and veins, have been recently identified as possible originators of mesenchymal stem cells, first by phenotypic analogies and eventually following stringent cell sorting. While it is clear that purified perivascular cells exhibit multiple mesodermal developmental potentials and become indistinguishable from conventionally derived mesenchymal stem cells after in vitro culture, the possible roles played by these blood vessel-bound cells in organogenesis and adult tissue repair remain elusive. Unsolved questions regarding the identity of mesenchymal stem cells have not compromised the consideration of these cells as outstanding candidates for cell therapies. Better knowledge of the lineage affiliation, tissue distribution and molecular identity of mesenchymal stem cells will contribute to the development of more efficient, safer therapeutic cells.
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