期刊
ORGANOGENESIS
卷 6, 期 2, 页码 88-96出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/org.6.2.11464
关键词
scaling relationships; cell; organelle; size control; power law; allometry
资金
- Herbert Boyer Postdoctoral Fellowship
- Searle Scholars Program
- W.M. Keck Foundation
How size is controlled is a fundamental question in biology. In this review, we discuss the use of scaling relationships-for example, power laws of the form y proportional to x(alpha)-to provide a framework for comparison and interpretation of size measurements. Such analysis can illustrate the biological and physical principles underlying observed trends, as has been proposed for the allometric dependence of metabolic rate or limb structure on organism mass. Techniques for measuring size at smaller length-scales continue to improve, leading to more data on the control of size in cells and organelles. Size scaling of these structures is expected to influence growth patterns, functional capacity and intracellular transport. Furthermore, organelles such as the nucleus, mitochondria and endoplasmic reticulum show widely varying morphologies that affect their scaling properties. We provide brief summaries of these issues for individual organelles, and conclude with a discussion on how to apply this concept to better understand the mechanisms of size control in the cellular environment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据