期刊
SYMMETRY-BASEL
卷 7, 期 4, 页码 2025-2037出版社
MDPI AG
DOI: 10.3390/sym7042025
关键词
asymmetric cell division; somatic stem cell; cell fate decision; hematopoiesis; hematopoietic stem cell; hematopoietic progenitor cell; CD133
资金
- Deutsche Forschungsgemeinschaft [GI 336/4-1]
- Ministry of Science, Innovation and Research of the German State of North Rhine-Westphalia/the Stem Cell Network North Rhine-Westphalia [323-400 012 13]
Somatic stem cells are rare cells with unique properties residing in many organs and tissues. They are undifferentiated cells responsible for tissue regeneration and homeostasis, and contain both the capacity to self-renew in order to maintain their stem cell potential and to differentiate towards tissue-specific, specialized cells. However, the knowledge about the mechanisms controlling somatic stem cell fate decisions remains sparse. One mechanism which has been described to control daughter cell fates in selected somatic stem cell systems is the process of asymmetric cell division (ACD). ACD is a tightly regulated and evolutionary conserved process allowing a single stem or progenitor cell to produce two differently specified daughter cells. In this concise review, we will summarize and discuss current concepts about the process of ACD as well as different ACD modes. Finally, we will recapitulate the current knowledge and our recent findings about ACD in human hematopoiesis.
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