期刊
ONCOTARGET
卷 5, 期 20, 页码 10058-10069出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.2460
关键词
human breast cancer cells; non-tumorigenic breast cells; epinephrine; adrenergic receptors
资金
- MINCyT-EcosSud Argentina-France
- Fundacion Roemmers
- PICT (ANPCyT) [103, 1571]
- PIP from CONICET [692]
- Fundacion Instituto de Biologia y Medicina Experimental
Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused opposite effects in non-tumorigenic (MCF-10A and HBL-100) and tumor cells (MCF-7 and MDA-MB-231). Thus, Epi, in non-tumor breast cells, as well as isoproterenol (beta-agonist), in all cell lines, maintained a benign phenotype, decreasing cell proliferation and migration, and stimulating cell adhesion. beta-AR expression and cAMP levels were higher in MCF-10A than in MCF-7 cells. beta(2)-AR knock-down caused a significant increase of cell proliferation and migration, and a decrease of cell adhesion both in basal and in Iso-stimulated conditions. Coincidently, beta(2)-AR over-expression induced a significant decrease of cell proliferation and migration, and an increase of cell adhesion. Therefore, beta(2)-AR is implied in cell phenotype and its agonists or antagonists could eventually complement cancer therapy.
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