期刊
ONCOTARGET
卷 5, 期 17, 页码 7549-7562出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.2273
关键词
TAK1; NF-kappa B signaling; ovarian cancer; high-grade tumor
资金
- Hong Kong Research Grants Council General Research Fund [HKU 761213M]
- Wong Check She Charitable Foundation
Transforming growth factor (TGF)-beta-activating kinase 1 (TAK1) is a serine/threonine kinase which is frequently associated with human cancer progression. However, its functional role in tumorigenesis is still controversial. Here, we report that TAK1 enhances the oncogenic capacity of ovarian cancer cells through the activation of NF-kappa B signaling. We found that TAK1 is frequently upregulated and significantly associated with high-grade and metastatic ovarian cancers. Mechanistic studies showed that Ser412 phosphorylation is required for TAK1 in activating NF-kappa B signaling and promotes aggressiveness of ovarian cancer cells. Conversely, suppression of TAK1 activity by point mutation at Ser412, RNAi mediated gene knockdown or TAK1 specific inhibitor ((5Z) -7-Oxozeaenol) remarkably impairs tumor growth and metastasis in ovarian cancer in vitro and in vivo. Our study underscores the importance of targeting TAK1 as a promising therapeutic approach to counteract the ovarian cancer progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据