期刊
ONCOTARGET
卷 6, 期 3, 页码 1435-1445出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.2935
关键词
Calcium (Ca2+); cell death; apoptosis; TRP53 (p53); mitochondria
资金
- Italian Association for Cancer Research (AIRC)
- University of Ferrara
- Italian Ministry of Education, University and Research
- NCI
One challenge in biology is signal transduction monitoring in a physiological context. Intravital imaging techniques are revolutionizing our understanding of tumor and host cell behaviors in the tumor environment. However, these deep tissue imaging techniques have not yet been adopted to investigate the second messenger calcium (Ca2+). In the present study, we established conditions that allow the in vivo detection of Ca2+ signaling in three-dimensional tumor masses in mouse models. By combining intravital imaging and a skinfold chamber technique, we determined the ability of photodynamic cancer therapy to induce an increase in intracellular Ca2+ concentrations and, consequently, an increase in cell death in a p53-dependent pathway.
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