期刊
ONCOTARGET
卷 4, 期 2, 页码 362-372出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.901
关键词
ACTN4; RelA/p65; transcription regulation; MMP
资金
- FEBS Collaborative Experimental Scholarship for Central and Eastern Europe
- RFBR [12-04-32194 mol_a, 10-04-00174, 12-04-32252 mol_a]
- Russian Government Programme for the Recruitment of the leading scientists into the Russian Institutions of Higher Education [11.G34.31.0069]
- Federal Target Program - Scientific and Pedagogical staff of innovative Russia [Pi174]
- Federal Programme for Scientific training in Innovative Russia [8280]
- MRC [MC_U132670600] Funding Source: UKRI
- Medical Research Council [MC_U132670600] Funding Source: researchfish
ACTN4 is an actin-binding protein that participates in cytoskeleton organisation. It resides both in the cytoplasm and nucleus and physically associates with various transcription factors. Here, we describe an effect of ACTN4 expression on transcriptional activity of the RelA/p65 subunit of NF-kB. We demonstrate that ACTN4 enhances RelA/p65-dependant expression of c-fos, MMP-3 and MMP-1 genes, but it does not affect TNC, ICAM1 and FN1 expression. Importantly, actin-binding domains of ACTN4 are not critical for the nuclear translocation and co-activation of RelA/p65-dependent transcription. Collectively, our data suggest that in the nucleus, ACTN4 functions as a selective transcriptional co-activator of RelA/p65.
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