期刊
NUTRIENTS
卷 6, 期 12, 页码 5756-5769出版社
MDPI
DOI: 10.3390/nu6125756
关键词
coenzyme Q10; wound healing; inflammation; alveolar socket
资金
- Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan [24593153]
- Grants-in-Aid for Scientific Research [24593153] Funding Source: KAKEN
Accelerating wound healing after tooth extraction is beneficial in dental treatment. Application of antioxidants, such as reduced coenzyme Q10 (rCoQ10), may promote wound healing after tooth extraction. In this study, we examined the effects of topical application of rCoQ10 on wound healing after tooth extraction in rats. After maxillary first molars were extracted, male Fischer 344 rats (8 weeks old) (n = 27) received topical application of ointment containing 5% rCoQ10 (experimental group) or control ointment (control group) to the sockets for 3 or 8 days (n = 6-7/group). At 3 days after extraction, the experimental group showed higher collagen density and lower numbers of polymorphonuclear leukocytes in the upper part of socket, as compared to the control group (p < 0.05). Gene expression of interleukin-1, tumor necrosis factor-alpha and nuclear factor-kappa B were also lower in the experimental group than in the control group (p < 0.05). At 8 days after tooth extraction, there were no significant differences in collagen density, number of polymorphonuclear leukocytes and bone fill between the groups. Our results suggest that topical application of rCoQ10 promotes wound healing in the soft tissue of the alveolar socket, but that rCoQ10 has a limited effect on bone remodeling in rats.
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