期刊
NUTRIENTS
卷 4, 期 3, 页码 154-166出版社
MDPI
DOI: 10.3390/nu4030154
关键词
intestinal immunity; lipid; IgA antibody; intraepithelial T lymphocytes; food allergy
资金
- Ministry of Education, Sports, Science, and Technology, Japan [22689015, 23116506, 23229004, 19059003]
- Ministry of Health and Welfare of Japan
- Global Center of Excellence of the Center of Education and Research for Advanced Genome-based Medicine
- Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry
- Yakult Bio-Science Foundation
- Grants-in-Aid for Scientific Research [23229004, 22689015, 24659217, 19059003] Funding Source: KAKEN
It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
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