期刊
NUCLEIC ACID THERAPEUTICS
卷 23, 期 1, 页码 2-8出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/nat.2012.0375
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资金
- The University of Texas M.D. Anderson Research Trust
- University of Texas System Regents Research Scholar
- CLL Global Research Foundation
- National Iinstitutes of Health/National Cancer Institute [CA135444]
- Department of Defense Breast Cancer Idea Award
- Developmental Research Award in Breast Cancer
- Developmental Research Award in Ovarian Cancer
- Developmental Research Award in Brain Cancer
- Developmental Research Award in Prostate Cancer
- Developmental Research Award in Multiple Myeloma
- Developmental Research Award in Leukemia SPOREs
- Laura and John Arnold Foundation
- RGK Foundation
- Estate of C. G. Johnson, Jr
The recent discovery of functional cell-free circulating microRNAs (miRNAs) in human body fluids has opened new avenues for the application of non-coding RNAs (ncRNAs) as noninvasive, specific and sensitive biomarkers for cancers and other human diseases. In this review, we explore the concept of circulating miRNAs as hormones, and discuss their potential functions in cellular communication and transferring of signals. We also provide a brief overview of their identification, processing, and potential functions and applications in human diseases.
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