期刊
NEUROSCIENCE BULLETIN
卷 30, 期 2, 页码 271-281出版社
SPRINGER
DOI: 10.1007/s12264-013-1423-y
关键词
Alzheimer's disease; oxidative stress; beta-amyloid; tau; metals; antioxidants
资金
- National Basic Research Development Program (973 Program) of China [2011CBA00400]
- National Natural Science Foundation of China [91332201]
- Natural Science Foundation of Shanghai Municipality, China [13JC1401500]
- fund for Medical Emerging Cutting-edge Technology in Shanghai Municipality, China [SHDC12012114]
Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a devastating disease of the elderly. The brain is more vulnerable than other organs to oxidative stress, and most of the components of neurons (lipids, proteins, and nucleic acids) can be oxidized in AD due to mitochondrial dysfunction, increased metal levels, inflammation, and beta-amyloid (A beta) peptides. Oxidative stress participates in the development of AD by promoting A beta deposition, tau hyperphosphorylation, and the subsequent loss of synapses and neurons. The relationship between oxidative stress and AD suggests that oxidative stress is an essential part of the pathological process, and antioxidants may be useful for AD treatment.
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