期刊
NEUROSCIENCE BULLETIN
卷 30, 期 2, 页码 191-197出版社
SPRINGER
DOI: 10.1007/s12264-013-1419-7
关键词
miR-206; brain-derived neurotrophic factor; APP/PS1; cell death; Alzheimer's disease
资金
- National Natural Science Foundation of China [91132718]
MicroRNA alterations have been reported in patients with Alzheimer's disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.
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