期刊
NEUROSCIENCE BULLETIN
卷 30, 期 3, 页码 497-504出版社
SPRINGER
DOI: 10.1007/s12264-013-1403-2
关键词
PKD; neuronal polarity; pain modulation; neuroprotection; learning
资金
- National Natural Science Foundation of China [81161120497, 30925015, 30830044, 30900582, 81221002]
- National Basic Research Development Program (973 Program) of China [2014CB542204]
Protein kinase D (PKD) is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, including G-protein-coupled receptor agonists and growth factors. PKD1 is the most studied member of the family. It functions during cell proliferation, differentiation, secretion, cardiac hypertrophy, immune regulation, angiogenesis, and cancer. Previously, we found that PKD1 is also critically involved in pain modulation. Since then, a series of studies performed in our lab and by other groups have shown that PKDs also participate in other processes in the nervous system including neuronal polarity establishment, neuroprotection, and learning. Here, we discuss the connections between PKD structure, enzyme function, and localization, and summarize the recent findings on the roles of PKD-mediated signaling in the nervous system.
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