期刊
NATURE CLINICAL PRACTICE ONCOLOGY
卷 5, 期 4, 页码 194-204出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncponc1051
关键词
angiogenesis; antivascular agents; biomarkers; clinical trials; ovarian cancer
类别
资金
- NCI NIH HHS [CA110793, CA109298, P50 CA083639] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P50CA083639, R01CA109298, R01CA110793] Funding Source: NIH RePORTER
Angiogenesis is a complex and highly regulated process that is crucial for tumor growth and metastasis. Insights into the molecular mechanisms of tumor angiogenesis have led to the identification of potential angiogenic targets and the development of novel antivascular agents. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This Review highlights the results of the latest clinical studies of antivascular agents in ovarian cancer and discusses the challenges and opportunities for future clinical trials.
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