期刊
MATERIALS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ma11091749
关键词
bioink; 3D bioprinting; biomaterials; stem cells; cartilage; meniscus; osteoarthritis; 4D printing; organ-on-a-chip
类别
资金
- Progetti Regione Emilia-Romagna POR-FESR 2014-2020: CUSTOM IMPLANTS
- 5 x 1000 funds, Italian Ministry of Health
Cartilage lesions fail to heal spontaneously, leading to the development of chronic conditions which worsen the life quality of patients. Three-dimensional scaffold-based bioprinting holds the potential of tissue regeneration through the creation of organized, living constructs via a layer-by-layer deposition of small units of biomaterials and cells. This technique displays important advantages to mimic natural cartilage over traditional methods by allowing a fine control of cell distribution, and the modulation of mechanical and chemical properties. This opens up a number of new perspectives including personalized medicine through the development of complex structures (the osteochondral compartment), different types of cartilage (hyaline, fibrous), and constructs according to a specific patient's needs. However, the choice of the ideal combination of biomaterials and cells for cartilage bioprinting is still a challenge. Stem cells may improve material mimicry ability thanks to their unique properties: the immune-privileged status and the paracrine activity. Here, we review the recent advances in cartilage three-dimensional, scaffold-based bioprinting using stem cells and identify future developments for clinical translation. Database search terms used to write this review were: articular cartilage, menisci, 3D bioprinting, bioinks, stem cells, and cartilage tissue engineering.
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