期刊
MATERIALS
卷 7, 期 5, 页码 3946-3955出版社
MDPI AG
DOI: 10.3390/ma7053946
关键词
marine biomaterials; tissue engineering; chitosan; carbon nanotube; antimicrobial activity
类别
资金
- Marine Bioprocess Research Center of the Marine Biotechnology Program - Ministry of Oceans and Fisheries, Republic of Korea
In the present study, we have prepared chitosan-carbon nanotube (Chitosan-CNT) hydrogels by the freeze-lyophilization method and examined their antimicrobial activity. Different concentrations of CNT were used in the preparation of Chitosan-CNT hydrogels. These differently concentrated CNT hydrogels were chemically characterized using Fourier Transform-Infrared Spectroscopy, Scanning Electron Microscopy and Optical microscopy. The porosity of the hydrogels were found to be >94%. Dispersion of chitosan was observed in the CNT matrix by normal photography and optical microscopy. The addition of CNT in the composite scaffold significantly reduced the water uptake ability. In order to evaluate antimicrobial activity, the serial dilution method was used towards Staphylococcus aureus, Escherichia coli and Candida tropicalis. The composite Chitosan-CNT hydrogel showed greater antimicrobial activity with increasing CNT concentration, suggesting that Chitosan-CNT hydrogel scaffold will be a promising biomaterial in biomedical applications.
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