期刊
MAGNETIC RESONANCE IN MEDICAL SCIENCES
卷 13, 期 1, 页码 7-13出版社
JPN SOC MAGNETIC RESONANCE IN MEDICINE
DOI: 10.2463/mrms.2013-0056
关键词
advanced imaging techniques; anterior eye segment; magnetic resonance imaging; 3D imaging
资金
- JSPS KAKENHI [25293263, 24659562, 24591754, 24791288]
- Grants-in-Aid for Scientific Research [24591754, 24659562, 25293263, 24791288] Funding Source: KAKEN
Purpose: Heavily T-2-weighted, 3-dimensional, fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) imaging has been reported to detect low concentrations of gadolinium-based contrast media (GBCM) in the anterior eye segment (AES), subarachnoid space (SAS), and labyrinthine perilymph as well as in the cerebrospinal fluid (CSF) of the internal auditory canal (IAC) 4 hours after intravenous administration of a single dose (IV-SD-GBCM) in patients with inner ear disorders. To elucidate the time course of contrast enhancement in healthy volunteers, we obtained hT(2)W-3D-FLAM serially after IV-SD-GBCM. Materials and Methods: We obtained hT2W-3D-FLAIR before and 0.5, 1.5, 3, 4.5 and 6 hours after IV-SD-GBCM in 6 healthy volunteers and measured signal intensity of the AES, SAS surrounding the optic nerve (SAS-ON), SAS in Meckel's cave (SAS-MC), pontine parenchyma, CSF in the IAC (CSF-IAC), CSF in the ambient cistern (CSF-AC), CSF in the lateral ventricles (CSF-LV), perilymph (PL), and endolymph (EL) in the labyrinth. We then compared averaged values among all time points using analysis of variance (ANOVA). Results: After IV-SD-GBCM, we observed no change in signal intensity in the pontine parenchyma, CSF-LV, or EL and significant enhancement in all other structures. Maximum enhancement was most frequent at 4.5 hours after IV-SD-GBCM in the SAS-ON and PL, at 1.5 hours in the AES and SAS-MC, and at 3 hours in the CSF-IAC and CSF-AC. Conclusions: Contrast enhancement can be detected by hT2W-3D-FLAIR in the AES, SAS-ON, SAS-MC, PL, CSF-IAC, and CSF-AC in healthy volunteers after IV-SD-GBCM. Timing of maximum enhancement differed among locations. These data might serve as basic knowledge for future clinical research.
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